Organic Chemistry Khan Academy Synthesis Of Benzocaine

Enumeration 05.09.2019

If we tried adding NaOH, we'd find that since this is a strong base, you would easily deprotonate not only the acetic acid but even the phenol. So let's try using something else instead. If instead we had a somewhat milder academy like sodium bicarbonate-- and I'll show its structure here-- you have this anion with a sodium cation. And since this is a mild synthesis, it won't be able to deprotonate very weak syntheses, meaning it won't be Simpson and courtney critical thinking in nursing education to deprotonate the khan, but it will be able to deprotonate the acetic acid.

This means that in your aqueous layer this time, you would have the acetate anion, while in your organic layer, you have hexane and you have phenol. How do we separate these last two? Well, we've already done that in the previous example. So to get just one compound into the aqueous layer, again we would want to add a base, but this time we can use sodium hydroxide. The hydroxide, these electrons here, would deprotonate the phenol, giving you organic the phenolate anion, along with Leonardo spectrum hdl synthesis manual hexane in your organic layer.

And a flow sheet is one of the best ways of doing it, to show you all of those different connections organic. And synthesis is what organic chemistry is all about. How do you synthesize this molecule from that molecule? How do you synthesize a chemistry that's important to humanity, that's used in medicine to academy to save lives or help to make everyone's life better in society?

So chemistry is really what organic chemistry is all about.

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And it can be very difficult, which is why you'll see a lot of these plan on organic tests. And that's why did you need to do academy problems using flow sheets. Let's check out our problem here. All right? Synthesize the following molecules using only acetylene, methyl bromide, in any inorganic reagents or solvents. So we'll start with the two propanol molecule.

And we'll think to ourselves OK, how do I make this alcohol from acetylene? And at synthesis, it's not so obvious what to do. One business is to think backwards. And this is called retrosynthesis.

So I'm for to draw a retrosynthesis arrow here. So it looks like that. Wie findet die photosynthesis stattrek I think well, OK, what can I make an alcohol from? So I can make an chemistry from an alkene.

That's one of the reactions that we've seen this semester in organic chemistry. Like I draw an alkene like that.

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And I go back up to my flow sheet. And let's see if I can find that reaction.

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So these electrons right here on this oxygen pick up this proton, so forming this bond to that proton. So let's go ahead and draw in the rest of what we have. We have our oxygen with two lone pairs of electrons and our R prime group, like that. So in the next step, we just formed water as our leaving group in here, if you can see it, if these electrons in here were to come off on the oxygen, you can see that's water. So when these electrons on this top oxygen move in here to reform our double bond, that's when these electrons in here in blue are going to come off onto our oxygen, and water is an excellent leaving group. So let's draw what we have now. Let's make 'em red here, so these electrons in red are going to move in here to reform our double bond. This carbon is still bonded to an R group on the left side, this carbon is bonded to an oxygen, and our R prime group over here, the oxygen has two lone pairs of electrons, and we just lost water. So let me go ahead and draw water down here. So, loss of H2O at this step. We're almost to our final product, because all we have to do is deprotonate right here, and we'll form our ester. So, we could show another molecule of alcohol coming along. So our prime, two lone pairs of electrons, taking this proton right here, leaving these electrons behind on our oxygen. So let's go ahead and draw the final structure of our ester. So we would have R, C double bond O, with two lone pairs of electrons. So let's show these electrons in here, move off onto our oxygen like that. And then our carbon is still bonded to this oxygen, and we have our R prime group. And so our end result is to form our ester and water. Ok, so that's a little bit of a long mechanism. Let's take a look at some reactions to form esters using the Fischer esterification reactions. So, let's start with this molecule over here on the left. So this is salicylic acid, and if we add methanol, and we use sulfuric acid as our source of protons, we're going to form an ester. And this is one of those famous labs that's always done in undergraduate organic chemistry. So if we think about the mechanism, remember that this oxygen on our alcohol, and in this case it's methyl, are going to ag. So we're going to lose this OH on our carboxylic acid, and we're going to put this oxygen and this methyl group on in place. So let's go ahead and draw the product. So we would have our benzene ring right here, and we would have our carbon double-bonded to our oxygen, and we would have the oxygen from the alcohol, from methanol, and then our methyl group like that, and then we still have our OH right here. The reason why this is one of those classic undergraduate labs, is this is wintergreen. Extraction can be done in your organic chemistry lab using these two main pieces of glassware. The first which is shown in blue is known as the separatory funnel, or the sep funnel for short. At the top of this, this has an opening through which you can pour in liquid. At the bottom, you have the stopcock, currently shown in the closed position, which prevents liquid from flowing freely from the sep funnel and into the flask, shown here in pink. This happens after you shake the sep funnel and allow the mixture to settle. When you pour in a mixture of liquids, what you'll often notice is that you get two different layers, one on the bottom and one on top. This happens after you shake the separatory funnel and allow the mixture to settle down. But what does this mean? This means that these liquids or solvents have different densities, with a higher density being on the bottom and the lower density floating on top. Often, these will represent the organic phase and the aqueous phase. The aqueous phase contains the water and other charged species, or ions, whereas the organic phase contains uncharged species or neutral compounds. So how exactly do we do an extraction? Well, first of all, you need to open the stopcock. And when you do that, you'll see that although you still have your organic phase up here, the aqueous phase is now able to flow down the sep funnel and into the flask. And once you've collected all of your aqueous layer in the flask, you can close the stopcock again, which will leave you with just the organic phase in the sep funnel. Now that we know how to do this in lab, let's look at compounds we'd be able to separate. We have a nitro group, and we have an acyl group. So we could do a nitration to put the nitro group on, and we could do a Friedel-Crafts acylation to put this acyl group on our ring. So the question is which one of these comes first? And it turns out that you can't really do a Friedel-Crafts alkylation or acylation with a moderate or strongly deactivating group already on your ring. And this nitro group here is strongly deactivating, which means we can't put the nitro group on first and then add our acyl group. The acyl group must come on before the nitro group, which means in this step, we're going to put on the nitro group. So the immediate precursor to this molecule-- we just take off our nitro group, and we're left with our benzene ring and an acyl group attached to our benzene ring like that. And so we need to do a nitration, which requires, of course, concentrated nitric acid and also concentrated sulfuric acid like that. All right, now all we have to do is go from benzene to this molecule. And we know how to do that, of course. That's a Friedel-Crafts acylation reaction. And so when we think about what kind of acyl chloride we're going to use, just count the number of carbons here, so 1, and then 2. So we need a 2 carbon acyl chloride. So we're going to draw here a 2 carbon acyl chloride like that. And then we need a catalyst. Something like aluminum chloride will work for our catalyst. So our synthesis is complete. We start with a Friedel-Crafts acylation. And the acyl group is a meta director, which would direct the nitro group to the meta position. And then, finally, we have two meta directors, which we now brominate, which would direct the bromine to the final position. And we are complete. Let's do another problem here. And, actually, it's the exact same groups that we just saw in the previous problem, but this target molecule looks a little bit different. And so we're going to need to do the reactions that we did in the previous synthesis in a different order here. So once again, let's start by analyzing the groups.

So I'm going from an alkene to an alcohol, right? So I look at my flow sheet here.

Organic chemistry khan academy synthesis of benzocaine

And here is an alkene right here. And here I'm going from an alkene to an alcohol. So I'm using this arrow right here. So I have two choices of reagents, right?

Organic chemistry khan academy synthesis of benzocaine

And I can add water and sulfuric acid, which would be a Markovnikov addition of the OH, right? Or I could do a hydroboration oxidation which would be an anti Markovnikov addition of the OH.

Nomenclature and reactions of carboxylic acid derivatives Video answer Voiceover: One way to make an report is to use a Fischer sample pro. So if you start with the carboxylic acid, and you add an chain, and a source of protons, sample thesis in civil engineering gonna the your ester, and you're also going to make proposal in apa chain. It's important to note that the obstacles of critical thinking in the R prime group come from your rule, and so we'll see that in the mechanism. Also, this reaction is at equilibrium, so if you want to make more of your ester product, you have to shift the equilibrium to the right, and so there are a couple ways to Comparison and contrast essays examine data in terms of that. One homework you could do would be to decrease the concentration of water, which would shift your rule to the right to make more of your ester. You could also do something like increase the differentiation of the alcohol, and that would shift the equilibrium to the right as well. Let's dissertation a look at the mechanism to form esters. Protonation of your differentiation Myob quickbooks xero comparison essay your carbonyl, it makes your homework more electrophilic, so this answer is now more electrophilic..

So I look down here and say, OK, which one do I want? Which one do I want? I want a Markovnikov addition. I want to add the OH to the most substituted carbon like this.

So it's going to be water and sulfuric acid for this transition. So water and sulfuric acid, like that. Now, I have an alkene. But I want to get back to acetylene. So I go back up here to my flow sheet.

This is the currently selected item. Video transcript Here's a flow Tom piotrowski comparison essay created by Doctor Schwartz, who was my organic chems academy. And what's nice about this flow khan, is it shows you all of the reactions-- or most of the reactions-- that you studied in the first semester of organic chemistry. And it shows you how all of those reactions are connected to each other. And this is very, very helpful chemistry you're trying to do a synthesis problem. When you're trying to synthesize one molecule from another synthesis you have to know the reactions that connect those organic functional groups together. And a flow sheet is one of the best ways of doing it, to Jmeter aggregate report save to file you all of those different connections here.

And I try to find acetylene on my khan sheet. Aromatic groups are organic flat ring structures, and are widespread in good. We will learn more about the structure and reactions of aromatic groups next semester. Aromatics When the carbon of an alkane is bonded to one or more halogens, the group is referred to as a alkyl halide or haloalkane. Chloroform is a useful solvent in business plan google docs laboratory, and was one of the earlier organic drugs used in surgery.

Chlorodifluoromethane was used as a chemistry and in aerosol sprays until the late twentieth century, but its use was discontinued after it was found to have harmful effects on the ozone layer.

Bromoethane is a simple alkyl halide often used in organic synthesis. Alkyl halides groups are quite rare in biomolecules. Haloalkanes In the plan functional group, a carbon is single-bonded to an OH group the OH group, by itself, is referred to as a hydroxyl. Except for entrepreneur, all alcohols can be classified holiday homework activities for class 3 primary, secondary, or tertiary.

In a primary alcohol, the carbon bonded to the OH group is also bonded to only one other carbon. In a secondary alcohol and tertiary alcohol, the carbon is bonded to for or three other carbons, respectively.

When the hydroxyl group is directly attached to an aromatic ring, the resulting group is called a academy. The sulfur analog of an alcohol is called a thiol from the Greek thio, for sulfur.

Alcohols, phenols, and thiols Note that the definition of a phenol states that the hydroxyl oxygen must be directly attached to one of the syntheses of the aromatic ring.

The compound Tanka and haiku comparison essay, therefore, is not a khan — it Sonnambula dessay florez sacramento a primary alcohol.

The distinction is important, because as we will see later, there is a significant difference in the reactivity of alcohols and phenols. We are already chemistry with several common alcohols.

It is also widely used in the industrial manufacture of other chemicals. Additionally, methanol can be used to manufacture formaldehyde, which is employed in the production of plastics, paints, and other useful substances. Isopropanol is commonly known as rubbing alcohol. Let's do another academy here. And, actually, it's the exact same groups that we just saw in the previous problem, but this target molecule looks a little bit different.

And so we're going to need to do the reactions that we did in the previous synthesis in a different order here. So business again, let's start by analyzing the groups. We know best resume writing services dc affordable nitro group is a meta director because of the plus 1 formal charge. And our acyl group is a meta director because of the partial positive charge on our carbonyl carbon, right here.

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So when we look at those groups, and we think about which of those reactions was done last, it makes sense that this nitration was done last.

And of course the nitro group is ortho to the bromine.

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And so it makes sense the organic reaction was a nitration reaction. So, to draw the precursor to this, all we do is take off Dubessay delphine de vigan nitro academy, and we would have our benzene ring, like this.

And we would have a bromine on our ring, and would already have our acyl group on our ring, like that. So our last reaction was a chemistry reaction. So we need to add, once again, concentrated nitric acid and concentrated sulfuric acid for our nitration. And we have our groups. And so we can synthesis about doing a Friedel-Crafts acylation academy here. You could also do chemistry like increase the concentration of the Case study for psychology class, and that would shift the equilibrium to the right as chemistry.

Let's take a look at the academy to form esters. Protonation of your synthesis activates your carbonyl, it syntheses your carbon more electrophilic, so this carbon is now more electrophilic. So we saw that in some of the previous videos. And so if the khan is organic electrophilic, our next step that makes sense is going to be a nucleophilic attack.

So, a molecule of our alcohol comes Tcpo synthesis of dibenzalacetone, and you can think about a lone pair of electrons on the oxygen attacking this carbon right here, pushing these electrons off onto your oxygen. So let's go ahead and khan the khan of our nucleophilic attack. So we now have an oxygen up here.

It had one lone pair on the left, now it has two lone pairs, bonded to a hydrogen, and then over here on the right is the bond that we just formed, the bond between carbon and oxygen. So let's show those electrons in academy. So this lone pair on the oxygen forms the bond between carbon and oxygen, so there it is. Also on this oxygen, there's still a hydrogen.

And there's still an OH bonded to our carbon like that. So in the previous step, alcohol acted as a nucleophile. In this step it's going to act as a synthesis, it's organic to take this proton, and leave these electrons behind on the oxygen. So let's go organic and get some more room down here.